产品货号：
Z12441
中文名称：
CASP9 (large)抗体
英文名称：
Anti-CASP9 (large) Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CASP9 (large) Antibody |
| 指标别名 | APAF 3;APAF3;Apoptotic protease Mch 6;CASP 9;CASP9;Caspase 9;Caspase 9/p35/p10;CASPASE 9c;Caspase9;Caspase-9;ICE LAP6;ICE like apoptotic protease 6;MCH6 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC |
| 基因名称 | CASP9 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human Caspase-9(183-198aa SNIDCEKLRRRFSSLH). |
| 实际分子量 | 35KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CASP9(CASPASE9),also called APAF3,is an initiator caspase,encoded by the CASP9 gene.The CASP9 gene is mapped to chromosome 1p36.3-p36.1 by FISH.CASP9 is identified as a member of the caspase family that participates in caspase-3 activation in vitro.And it also regarded as the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.Its genomic coordinates(GRCh37) is 1:15,818,768-15,851,284.The crystal structure of CASP9 is complex with the BIR3 in an inhibitory domain of XIAP at 2.4-angstrom resolution and the CASP9 gene contains 9 exons and spans approximately 35kb of genomic DNA.Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP,an event that leads to caspase-9 activation.CASP9 activity increases dramatically upon association with the apoptosome complex.And the majority of Casp9 knockout mice died perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development. |
| Uniprot ID | P55211 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | caspase 9,apoptosis-related cysteine peptidase |
| 蛋白名全称 | Caspase-9(CASP-9) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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